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Appearance:white powder
Throughput:100|Kilogram|Month
pd_productuse:API
Delivery Time:large stock
Purity:99% purity
Etilefrine hydrochloride Chemical Properties
Melting point 122 °C
solubility Freely soluble in water, soluble in ethanol (96 per cent), practically insoluble in methylene chloride
form neat
Safety Information
RIDADR UN 2811 6.1 / PGIII
RTECS DO5618000
MSDS Information
Etilefrine hydrochloride Usage And Synthesis
Chemical Properties White or almost white, crystalline powder or colourless crystals.
Originator Circupon,Troponwerke,W. Germany
Uses Adrenoceptor agonist.
Manufacturing Process 30 parts of 1-(3'-hydroxyphenyl)-2-(N-benzylaminomethyl)-ethan-1-one are mixed with 100 parts of pyridine and 30 parts of pivalic anhydride and dissolved while warming. After heating for 1 hour under reflux, the acylation is complete. After concentrating the reaction solution, the product is precipitated from acetone/ether. Yield: 96.4% of 1-(3'-pivaloyloxyphenyl)-2- (N-benzylaminomethyl)-ethan-1-one.
3 parts of palladium/charcoal (10% strength) are prehydrogenated in water, thereafter 10 parts of 1-(3'-pivaloyloxyphenyl)-2-(N-benzylaminoethyl)-ethan- 1-one, dissolved in a 10-fold amount of water, are added dropwise at room temperature and hydrogenation is carried out until 1 mol of hydrogen has been taken up. After filtering off the catalyst, a further 3 parts of palladium/charcoal are added and hydrogenation is carried out until a further mol of hydrogen has been taken up. The catalyst is separated off and after removal of the solvent the hydrogenation product is reprecipitated from acetone/petroleum ether and from methanol/ether until it is pure according to thin layer chromatography. Yield: 38.8% of 1-(3'-pivaloyloxyphenyl)-2- ethylaminoethanol-1 hydroxide, melting point 208°C to 209°C.
Therapeutic Function Tranquilizer
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