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Product Details

Appearance:white powder

Throughput:20|Metric Ton|Month

pd_productuse:An antihypertensive. An angiotensin converting enzyme (ACE) inhibitor, converted to active, diacid metabolite

Delivery Time:in stock

Purity:EP7.0

Description Ramipril (brand name: Altace) is a kind of prodrug which is capable of inhibiting the angiotensin-converting enzyme (ACE) which converting angiotensin I to angiotensin II. It is metabolized to ramiprilat in the liver which exerts the effect of ACE inhibition. It is used for the treatment of hypertension, congestive heart failure and nephropathy. It can also be used for the prevention of heart attack, stroke and cardiovascular death. It can also be used for the treatment of kidney damage due to diabetes with protein-containing urine. Ramiprilat, is the competitive inhibitor of ATI for binding to ACE, further inhibiting the enzymatic proteolysis of ATI to ATII, alleviating the effect of ATII on blood pressure.
References https://en.wikipedia.org/wiki/Ramipril
https://www.drugbank.ca/drugs/DB00178
Chemical Properties White Solid
Uses cardiotonic
Uses An inhibitor of the angiotensin- coverting enzyme (ACE)
Uses An antihypertensive. An angiotensin converting enzyme (ACE) inhibitor, converted to active, diacid metabolite
Uses Angiotensin-converting enzyme (ACE) removes the C-terminal dipeptide from angiotensin I to form angiotensin II, a powerful vasoconstrictor. ACE is a key regulator of the renin-angiotensin system and an important drug target for the treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications in diabetes. Ramipril is a second generation ACE inhibitor (IC50 = 4 nM) that acts as a prodrug, which is hydrolyzed in vivo to the active metabolite ramiprilat. The antihypertensive and cardioprotective efficacy of ramipril has been demonstrated in large-scale noncomparative studies and clinical trials.[Cayman Chemical]
Ramipril Preparation Products And Raw materials
Raw materials Ethyl acetate-->Dichloromethane-->Acetic acid glacial-->Cyclohexane-->Formamide-->Tetrahydro pyrrole-->L-Alanine-->Methyl propionate-->Cyclopentene-->Palladium carbon fine chemical catalyzer-->Ethyl 3-benzoylacrylate