2124-57-4

Product Details

Appearance:Light Yellow Crystalline Solid

Throughput:100|Kilogram|Month

pd_productuse:API

Delivery Time:large stock

Purity:99% purity

Vitamin K2(35) Usage And Synthesis
Description    Menaquinone 7 (MK-7) is a vitamin K2 analog that has been found in a variety of fermented foods. It increases osteocalcin, osteoprotegerin, and RANKL mRNA expression in osteoblastic MC3T3E cells. MK-7 (1 μM) increases alkaline phosphatase activity and calcium content in femoral-metaphyseal tissues isolated from normal and skeletal-unloaded rats. In vivo, MK-7 (100 μg/g diet) inhibits aortic and myocardial calcification and decreases aortic alkaline phosphatase tissue concentrations in a rat model of extraosseous calcification. It also increases trabecular number, bone mineral density, and bone mineral content in a rat model of ovariectomy-induced bone loss.
Chemical Properties    Light Yellow Crystalline Solid
Uses    Vitamin (prothrombogenic)
Uses    Menaquinones are isoprenoid quinones of the naphthalene series and belongs to the K2 Vitamin homologs. Menaquinones were originally discovered as the anti-hemorrhagic factor and now encompasses a vari ety of physiological processes. Menaquinone 7 belongs to the class of K2-Vitamins homologs. Menaquinone 7 has been identified as the most bioactive cofactor for the carboxylation reaction of Gla-prote ins such as osteocalcin and matrix-Gla protein, which plays a crucial role in building and maintaining overall bone health.
Uses    
Vitamin K2 (MK-7)-(5,6,7,8-d4,2-methyl-d3) can be used as a stable isotope internal standard for data interpretation in specific biological samples.
Definition    ChEBI: A menaquinone whose side-chain contains seven isoprene units in an all-trans-configutation.
General Description    
Vitamin K2, also known as menaquinone, is a polyisoprenoid-substituted napthoquinone. Menaquinone-7 (MK-7) is a subtype of vitamin K2. It is found in animals, soy protein, fermented products and is primarily produced by bacteria.
Vitamin K2 (MK-7)-(5,6,7,8-d4,2-methyl-d3) is a deuterated vitamin K2 wherein C-5, C-6, C-7, C-8, and 2-methyl protons are replaced by deuterium.