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Appearance:powder
Throughput:100|Kilogram|Day
pd_productuse:intermediate
Delivery Time:in stock
Purity:98% purity
Melting point 214 °C(dec.)
Boiling point 662.4±55.0 °C(Predicted)
density 1.373
Fp 354.4℃
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility DMSO: 10 mg/mL, soluble
pka 10.14±0.10(Predicted)
form powder
InChIKey FHYUGAJXYORMHI-UHFFFAOYSA-N
Safety Information
Safety Statements 22-24/25
WGK Germany 3
HS Code 29349990
MSDS Information
SB 431542 Usage And Synthesis
Uses SB 431542 is a known Src family kinase inhibitor that effectively blocks the transforming growth factor-β1-induced cell migration and invasion in both established and primary carcinoma cells.
Definition ChEBI: A member of the class of benzamides that is 4-(imidazol-2-yl)benzamide carrying additional 1,3-benzodioxol-5-yl and pyridin-2-yl substituents at positions 4 and 5 respectively on the imidazole ring.
Biological Activity Potent and selective inhibitor of the transforming growth factor- β (TGF- β ) type I receptor activin receptor-like kinase ALK5 (IC 50 = 94 nM), and its relatives ALK4 and ALK7. Suppresses TGF- β -induced proliferation of human osteosarcoma cells. Stimulates proliferation, differentiation and sheet formation of ESC-derived endothelial cells.
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