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Appearance:powder
Throughput:100|Kilogram|Month
pd_productuse:Sevelamer hydrochloride is a noncalcemic phosphate binder for the treatment of hyperphosphatemia in chronic renal failure.
Delivery Time:in stock
Purity:99% purity
Originator Renagel,Chugai Pharmaceutical
Uses Sevelamer hydrochloride is a noncalcemic phosphate binder for the treatment of hyperphosphatemia in chronic renal failure.
Uses Sevelamer HCl is used in the treatment of hyperphosphataemia in patients suffering from chronic kidney disease.
Manufacturing Process Poly(allylamine hydrochloride) (50% w/w, 426 kg) was charged to a 1000 L reactor and water (200 L) was added. Sodium hydroxide solution (32% w/w, 208 kg) was added, followed by 85 L of water. The mixture was stirred for 1 h and filtered to a 2500 L reactor. The transfer line was rinsed with water (217 kg) and acetonitrile (1300 L) added. The temperature was adjusted to 40°C and epichlorohydrin (20 kg) added. The mixture was stirred at 40° to 50°C for 1.5 h and then heated to reflux for 16 h. The resulting product slurry may be isolated and washed in decanter centrifuge.
Brand name Renagel (Genzyme).
Therapeutic Function Antihyperphosphatemic
Veterinary Drugs and Treatments Sevalamer may be useful for treating hyperphosphatemia associated with chronic renal failure, particularly when oral aluminum salts are not tolerated.
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