Appearance:colourless liquid
Purity:99%
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108-75-8 Name |
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Name |
2,4,6-Collidine |
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Synonym |
2,4,6-Kollidin;2,4,6-trimethyl-pyridin;a,g,a'-Collidine;alpha,gamma,alpha’-collidine;alpha,gamma,alpha'-Collidine;g-Collidine;Pyridine,2,4,6-trimethyl-;2 Minus 2-3 Methyl pyridine |
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108-75-8 Chemical & Physical Properties |
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Melting point |
−43 °C(lit.) |
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Boiling point |
171.0±9.0 °C at 760 mmHg |
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Density |
0.9±0.1 g/cm3 |
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Molecular Formula |
C8H11N |
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Molecular Weight |
121.180 |
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Flash Point |
57.2±0.0 °C |
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PSA |
12.89000 |
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LogP |
2.11 |
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Exact Mass |
121.089149 |
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Vapour Pressure |
1.9±0.3 mmHg at 25°C |
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Index of Refraction |
1.502 |
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Storage condition |
2-8°C |
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Stability |
Stable. Combustible. Incompatible with strong oxidizing agents. |
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Water Solubility |
35 g/L (20 ºC) |
2,4,6-Trimethylpyridine is a pyridine derivative. It has a pK of 7.4. The product can react with trifluoroiodomethane in cyclopentane solution to afford 1:1 complex. 2,4,6-collidine can used as monomer to produce a series of highly crystalline olefin-linked COFs by a melt polymerization method. This complex was investigated by NMR (Nuclear Magnetic Resonance) spectroscopy. 2,4,6-Collidine is used as a tissue fixative for electron microscopy. It is useful in dehydrohalogenation reactions and acts as a solvent for the cleavage of hindered esters by anhydrous lithium iodide. The crystal structure of 2,4,6-collidine (2,4,6-trimethylpyridine, C8H11N) has been determined at 180 (2) K following in situ crystal growth from the liquid.
Definition
Methyl, ethyl, propyl, and trimethyl homologs of pyridine.
InChI:InChI=1/C8H11N/c1-6-4-7(2)9-8(3)5-6/h4-5H,1-3H3
The association of pyridine and of 2,4,6-trimethylpyridine (collidine) with a pyramidal triarylborane belonging to the 9-boratriptycene family is investigated by NMR spectroscopy and by X-ray diffraction analysis. Despite of the large size of the ortho-disubstituted collidine Lewis base and of the large steric hindrance of the boron Lewis superacid used (9-boratriptycene-10-sulfonium), the superacidity at its boron atom is enabling the formation of a B-N bond and is resulting in a very stabe Lewis adduct.
In this report we describe further extension of the research on other derivatives of 3,5-diaryl substituted 2,4-, 2,6-lutidines and 2,4,6-collidines. In summary, we prepared a library of compounds using the Suzuki–Miyaura cross-coupling reaction between 3,5-dibromo-2,4,6-collidine and bromo derivatives of 2,6- and 2,4-lutidine with a series of ortho-substituted boronic acids.
2,4,6-Trimethylpyridiniumkation
naphthalene-1,4-diol; deprotonated form
2,4,6-trimethyl-pyridine
1,4-Dihydroxynaphthalene
| Conditions | Yield |
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In acetonitrile; at 20 ℃; Equilibrium constant;
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2,4,6-trimethylpyridinium picrate
2,4,6-trimethyl-pyridine
2,4,6-Trinitrophenol
| Conditions | Yield |
|---|---|
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In acetic acid; at 25 ℃; Equilibrium constant;
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2,6-dimethylpyridine
2,2,4,6-tetramethyl-2,3-dihydropyridine
3,5-dimethyl-2-cyclohexen-1-one
3-Methylbutenoic acid
3β-benzoyloxycholesta-5,7-diene
2-(4,6-dimethylpyridin-2-yl)ethanol
4,6-dimethyl-2-vinylpyridine
2-(2,6-dimethyl-[4]pyridyl)-propane-1,3-diol
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