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Products > API & intermediates > > Losartan potassium
Product name : Losartan potassium
CAS : 124750-99-8
Molecular Formula : C22H23ClKN6O
Standard : USP32
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Details:

Synonyms: 2-BUTYL-4-CHLORO-1-[[2'-(1H-TETRAZOL-5YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1H-IMIDAZOLE-5-METHANOL;2-butyl-4-chloro-1-[[2'-(1h-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1h-imidazole-5-methanol monopotassium salt;2-BUTYL-4-CHLORO-1-[[2'-(1H-TETRAZOLE-5-YL)[1,1'-BIPHENYL]-4-YL]METHYL]-1H-IMIDAZOLE-5-METHANOL, POTASSIUM SALT;COZAAR;DUP 753;LOSARTAN MONOPOTASSIUM SALT;LOSARTAN POTASSIUM;LOSARTAN POTASSIUM SALT 

Function and Usage:

Losartan is a selective, competitive angiotensin II receptor type 1 (AT1) receptor antagonist, reducing the end

organ responses to angiotensin II. Losartan administration results in a decrease in total peripheral resistance

(afterload) and cardiac venous return (preload) All of the physiological effects of angiotensin II, including stimulation

 of release of aldosterone, are antagonized in the presence of losartan. Reduction in blood pressure occurs independently

 of the status of the renin angiotensin system. As a result of losartan dosing, plasma renin activity increases due to removal of the angiotensin II feedback.

Losartan is a uricosuric. Because losartan can cause hyperkalemia, potassium supplements or salt substitutes containing potassium

should not be used without appropriate monitoring by a physician.



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